The goal of the Dagstuhl Perspectives Workshop 16472 has been to discuss and outline the stra- tegic evolution of Quality of Experience as a key topic for future Internet research. The resulting manifesto, which is presented here, reviews the state of the art in the Quality of Experience (QoE) domain, along with a SWOT analysis. Based on those, it discusses how the QoE research area might develop in the future, and how QoE research will lead to innovative and improved products and services. It closes by providing a set of recommendations for the scientific community and industry, as well as for future funding of QoE-related activities.